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Technical
Information
Vial
Finish Specifications
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Standard
Screw Thread Finish
"T"
= Outer diameter of the thread
"E" = Inside diameter of the thread
"ID" = Inside diameter
"S" = Start of thread
"H" = Distance from top of finish to shoulder for
closure clearance |
Standard
Crimp Seal Finish
"T"
= Outer diameter of seal
"E" = Crimp tool and robotic arm clearance
"ID" = Inside diameter
"A" = Crimp seal thickness
"H" = Distance from top to shoulder for crimp and
robotic arm clearance |
Screw
Thread Finishes
| GPI
refers to the "Glass Packaging Institute"
The
GPI is responsible for establishing and issuing standards
for the types and finishes produced by American glass
manufacturers.
For
example, and 8-425 neck finish is approximately 8 mm in
diameter across the outside of the threads.
The
425 represents the finish (style of thread).
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Typical
GPI finishes found in the chromatography
field are as follows:
8-425
Closure - Varian, Shimadzu
10-425 Closure - Waters Alliance 2690
13-425 Closure - Waters 48 position WISP™, Shimadzu
Note:
9 mm thread finish does not appear in the GPI finishes.
It is not a standard finish. The 9 mm closure and vial are
used with Hewlett-Packard equipment. |
Glass
Technical Information
Terminology
Borosilicate
- A glass that is high in silicate and having at least
5% boron oxide.
Linear
Coefficient of Expansion - Fractional change
in length of glass per degree change in temperature.
Strain
Point - Maximum temperature to which glass should
be heated during use.
Types
of Glass
USP
Type - Pharmaceutical glass containers can be
classified as USP Type I, II, III or NP.
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Type
I - Borosilicate glass represents the least reactive
glass.
Type I glass has the least pH shift. (Lowest leaching characteristics)
Coefficient
of Expansion = 33 or 51 for Clear and 51 for Amber
Type
II - is de-alkalized soda lime glass with higher
levels of sodium hydroxide and calcium oxide.
Type
III - soda lime glass - cannot be autoclaved.
Type
NP - general purpose soda-lime glass used where
chemical durability and heat shock are not factors.
Coefficient
of Expansion = 92
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GLASS
PROPERTIES |
| Color |
Clear |
Amber |
| Linear
Coefficient of Expansion |
33 |
51 |
| Strain
Point (Degrees Celsius) |
515 |
535 |
| USP
Class Type |
Type
1 |
Type
1 |
| Light
Protection |
No |
Yes |
PLASTIC
PROPERTIES |
| Type
of Plastic |
LDPE |
HDPE |
PP |
PMP |
PS |
| Maximum
use temperature, C/F |
80°C/176°F |
120°C/248°F |
135°C/275°F |
175°C/347°F |
90°C/194°F |
| Transparency |
Translucent |
Translucent |
Translucent |
Clear |
Clear |
Sterilization |
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Autoclaving |
No |
No |
Yes |
Yes |
No |
Disinfectants |
Yes |
Yes |
Yes |
Yes |
No |
Dry
Heat |
No |
No |
No |
Yes |
No |
Radiation |
Yes |
Yes |
No* |
No |
Yes |
| Specific
Gravity |
0.92 |
0.95 |
0.90 |
0.83 |
1.05 |
| Flexibility** |
Good |
Rigid |
Rigid |
Rigid |
Rigid |
Note: Chart is general guideline only.
PP* = Some radiation resistant polypropylene resins available.
**Flexibility - Depends on thickness.
SEPTA
SELECTION GUIDE |
| Materials |
Compatability |
Incompatability |
Resealability |
| Silicone |
Alcohols,
acetone, ether, DMF,
DMSO |
ACN,
THF, chloroform, pyridine,
benezene, toluene, hexane, heptane |
VERY
GOOD |
PTFE/Silicone
PTFE/Silicone/PTFE |
PTFE
resistance until punctured
then septa or liner will have
silicone compatability |
|
VERY
GOOD
VERY GOOD |
Rubber
(Natural Butyl) |
ACN,
Acetone, DMF, alcohols
Diethylamine, DMSO, Phenol |
Chlorinated
solvents, aromatics,
hydrocarbons, carbon disulfide |
EXCELLENT |
Natural
PTFE/
Natural Rubber
Butyl PTFE/Butyl |
PTFE
resistance until punctured
then septa or liner will have
rubber compatability |
|
VERY
GOOD
VERY GOOD |
| Viton* |
Chlorinated
solvents, benezene,
toluene, alcohols, hexane, heptane |
DMF,
DMSO, ACN, THF, pyridine
dioxane, methanol, acetone
|
VERY
GOOD |
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