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Technical Information - Click here for PDF

Vial Finish Specifications

Vials finish spec Standard crimp seal finish Vials finish spec
Standard Screw Thread Finish
"T" = Outer diameter of the thread
"E" = Inside diameter of the thread
"ID" = Inside diameter
"S" = Start of thread
"H" = Distance from top of finish to shoulder for closure clearance
Standard Crimp Seal Finish
"T" = Outer diameter of seal
"E" = Crimp tool and robotic arm clearance
"ID" = Inside diameter
"A" = Crimp seal thickness
"H" = Distance from top to shoulder for crimp and robotic arm clearance

Screw Thread Finishes

GPI refers to the "Glass Packaging Institute" The GPI is responsible for establishing and issuing standards for the types and finishes produced by American glass manufacturers.

For example, an 8-425 neck finish is approximately 8mm in diameter across the outside of the threads.

The 425 represents the finish (style of thread).
Typical GPI finishes found in the chromatography field are as follows:

8-425 Closure - Varian, Shimadzu
10-425 Closure - Waters Alliance 2690
13-425 Closure - Waters 48 position WISP™, Shimadzu

Note: 9mm thread finish does not appear in the GPI finishes. It is not a standard finish. The 9mm closure and vial are used with Agilent equipment.

Glass Technical Information

Borosilicate - A glass that is high in silicate and having at least 5% boron oxide.

Linear Coefficient of Expansion - Fractional change in length of glass per degree change in temperature.

Strain Point - Maximum temperature to which glass should be heated during use.

Types of Glass
USP Type - Pharmaceutical glass containers can be classified as USP Type I, II, III or NP.
Type I - Borosilicate glass represents the least reactive glass.
Type I glass has the least pH shift. (Lowest leaching characteristics)
Coefficient of Expansion = 33 or 51 for Clear and 51 for Amber

Type II - is de-alkalized soda lime glass with higher levels of sodium hydroxide and calcium oxide.

Type III - soda lime glass - cannot be autoclaved.

Type NP
- general purpose soda-lime glass used where chemical durability and heat shock are not factors. Coefficient of Expansion = 92


Color Clear Amber
Linear Coefficient of Expansion 33 51
Strain Point (Degrees Celsius) 515 535
USP Class Type Type 1 Type 1
Light Protection No Yes


For a Comprehensive Listing of the Chemical Resistance to Membranes and Plate Matrices, download this PDF

Type of Plastic LDPE HDPE PP PMP PS
 Maximum use temperature, C/F 80°C/176°F 120°C/248°F 135°C/275°F 175°C/347°F 90°C/194°F
 Transparency Translucent  Translucent  Translucent  Clear   Clear
 No No Yes Yes No
 Yes Yes Yes Yes No
 Dry Heat
 No No  No   Yes No 
 Yes Yes No* No Yes
Specific Gravity 0.92 0.95 0.90 0.83 1.05
Flexibility** Good Rigid Rigid Rigid Rigid

Note: Chart is general guideline only.
PP* = Some radiation resistant polypropylene resins available.
**Flexibility - Depends on thickness.


Material Temp. Range Compatibility Incompatibility Resealability
Polypropylene (PP)
(Used in molded caps with a thin penetration point, such as snap caps or snap plugs.)
0°C - 135°C Acetone, ethyl acetate, methanol, isobutyl alcohol, methanol, and methyl ethyl ketone cyclohexane, ethers, dichlorobenzene, pentanes, methylene chloride, and trichlorobenzene For one time use only, not resealable. Not recommended for lengthy sample storage.
Polyethylene (PE) Used in molded caps with a thin penetration point, such as snap caps or snap plugs.) Maximum temperature use is 120°C Acids, alcohol, and bases benzene, chlorobenzene, acetic anhydride For one time use only, not resealable. Easily penetrated by syringe needles.
Polytetrafluoroethylene (PTFE) -265°C - 250°C Aliphatic hydrocarbons, aromatic hydrocarbons, alcohols, oils, gasoline, animal and vegetable oils, acids, and alkalies None For one time use only; not resealable. Not recommended for lengthy sample storage.
PTFE/Butyl and
Molded PTFE/Butyl
-40°C - 120°C Alcohols, animal and vegetable oils, acids Aliphatic hydrocarbons, aromatic hydrocarbons, oil, gasoline Good
PTFE/Red Rubber -40°C - 110°C ACN, acetone, DMF, alcohols, Diethylamine, DMSO, Phenol Aromatics, hydrocarbons, carbon disulfide Not recommended for mulitple injections or holding sample for future analysis.
PTFE/Silicone -40°C - 200°C Alcohols, acetone, ether, DMF, DMSO ACN, THF, chloroform, pyridine, benzene, toluene, hexane, heptanes Above average
PTFE/Silicone/PTFE -40°C - 200°C Alcohols, acetone, ether, DMF, DMSO Chlorosilanes, ACN, THF, chloroform, pyridine, benzene, toluene, hexane, heptanes Above average
Flouroelastomers (Viton*) -23°C - 204°C Chlorinated solvents, benezene,
toluene, alcohols, hexane, heptane
DMF, DMSO, ACN, THF, pyridine
dioxane, methanol, acetone
Very good


  • Graduated Vial™, R.A.M. Vial™, Scallop Pack™, Snap Rack™, Snap Ring™ Vial, Snap Top Cap™, Top Seal™ Closure and Multi-Tier™ are trademarks of J.G. Finneran Associates, Inc.
  • Capsule Holders™, Poly Crimp™ Seal, Snap Seal™ Vial, Top Hat™, Top Spring™ and 96-Well Multi-Tier™ MTP System are patented by J.G. Finneran Associates, Inc.
  • TPX™ is a trademark of Imperial Chemical Industries, Ltd.
  • Viton® is a registered trademark of E.I. DuPont.
  • Waters WISP™ is a trademark of Waters Corporation.
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